diff --git a/miniz.h b/miniz.h
index 42e1ea2..ec918d2 100644
--- a/miniz.h
+++ b/miniz.h
@@ -161,12 +161,15 @@
 #define MINIZ_X86_OR_X64_CPU 0
 #endif
 
+/* Set MINIZ_LITTLE_ENDIAN only if not set */
+#if !defined(MINIZ_LITTLE_ENDIAN)
 #if (__BYTE_ORDER__ == __ORDER_LITTLE_ENDIAN__) || MINIZ_X86_OR_X64_CPU
 /* Set MINIZ_LITTLE_ENDIAN to 1 if the processor is little endian. */
 #define MINIZ_LITTLE_ENDIAN 1
 #else
 #define MINIZ_LITTLE_ENDIAN 0
 #endif
+#endif
 
 /* Set MINIZ_USE_UNALIGNED_LOADS_AND_STORES only if not set */
 #if !defined(MINIZ_USE_UNALIGNED_LOADS_AND_STORES)